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Nick Dickenson

Profile Picture

Biochemistry

R. Gaurth Hansen Assistant Professor

Assistant Professor

Contact Information

Office Location: WIDT233
DialPhone: (435) 797-0982
SendEmail: nick.dickenson@usu.edu


Educational Background

PhD, University of Kansas, 2008
BS, Lewis Clark State College, 2003

Teaching Interests

I am interested in teaching at an interface between Chemistry and Biological Sciences. The molecular details afforded by "traditional" chemistry provide great insight into the biological processes that the students seem to be most interested in.

Research Interests

My research interests mirror my teaching interests in that I am investigating biological processes and interactions using analytical, biochemical, and biophysical techniques. One of the main focuses of the lab, currently, is the investigation of initial pathogen/host cell interaction preceding invasion by Shigella ssp.

Awards

USU College of Science Valedictorian Escort, 2015

R. Gaurth Hansen Assistant Professor Position, 2013

Utah State University

NIH (NIAID) Ruth L. Kirschstein National Research Service Award , 2009

National Institutes of Health

Ph.D. Defense, Honors Awarded, 2008

University of Kansas

J.K. Lee Award in Analytical Chemistry, 2008

University of Kansas

Dynamic Aspects of Chemical Biology NIH Predoctoral Program Award, 2005

NIH/University of Kansas

Emily V. Berger Award, 2003

University of Kansas

B.S. Cum Laude, 2003

Lewis Clark State College

Presidential Award, 1999

Lewis Clark State College

Publications - Abstracts

    Publications - Books & Book Chapters

      Book Chapters

    • Adam, P., Barta, M., Dickenson, N., Characterization of Type Three Secretion System Translocator Interactions with Phospholipid Membranes: Type 3 Secretion Systems: Methods and Protocols. Springer Publishing Company *
    • Barta, M., Adam, P., Dickenson, N., Recombinant Expression and Purification of the Shigella Translocator IpaB: Type 3 Secretion Systems: Methods and Protocols. Springer Publishing Company *
    • Arizmendi, O., Dickenson, N., , (2015). Dissecting Shigella flexneri Type III Secretion System Tip Complex Maturation: Shigella: Molecular and Cellular Biology. Caister Academic Press *
    • Dickenson, N., Mooren, O.L, Erickson, E.S, Dunn, R.C, (2014). Near-Field Scanning Optical Microscopy: A New Tool for Exploring Biological Structure and Function: Surface Analysis and Techniques in Biology. *

    * Has not been peer reviewed

    Publications - Fact Sheets

      * Has not been peer reviewed

      Publications - Curriculum

        * Has not been peer reviewed

        Publications - Journal Articles

          Academic Journal

        • Burgess, J.L, Burgess, R.A, Morales, Y., Bouvang, J.M, Johnson, S.J, Dickenson, N., (2016). Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. Journal of Biological Chemistry, 291:50, 25837-25852. doi: 10.1074/jbc.M116.755256
        • Bernard, A.R, Duarte, S., Kumar, P., Dickenson, N., (2016). Detergent isolation stabilizes and activates the Shigella type III secretion system translocator protein IpaC.. Journal of Pharmaceutical Science, 105:7
        • Burgess, J.L, Jones, H.B, Kumar, P., Toth, R., Middaugh, C., Antony, E., Dickenson, N., (2016). Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri.. Protein Science, 25, 1037-1048.
        • Chen, X., Choudhari, S., Martinez, F., Kim, J., Dickenson, N., Toth, R., Joshi, S., Greenwood, J., Clements, J., Picking, W., Middaugh, C., Picking, W., (2015). Impact of detergent on the biophysical properties and immune response of the IpaDB Fusion protein, a candidate subunit vaccine against Shigella spp.. Infection and Immunity, 83:1, 292-299. doi: 10.1128/IAI
        • Adam, P.R, Dickenson, N., Greenwood 2nd, J.C, Picking, W.L, Picking, W.D, (2014). Influence of Oligomerization State on the Structural Properties of Invasion Plasmid Antigen B (IpaB) from Shigella flexneri in the Presence and Absence of Phospholipid Membranes. PROTEINS: Structure, Function, and Bioinformatics
        • Martinez-Becerra, F.J, Chen, X., Dickenson, N., Choudhari, S.P, Harrison, K., Clements, J.D, Picking, W.D, Van De Verg, L.L, Walker, R.I, Picking, W.L, (2013). Characterization of a novel fusion protein of IpaB and IpaD of Shigella and its potential as a pan-Shigella vaccine. Infection and Immunity
        • Schönknecht, G., Chen, W., Ternes, C.M, Barbier, G.G, Shrestha, R.P, Stanke, M., Bräutigam, A., Baker, B.J, Banfield, J.F, Garavito, R.M, Benning, C., Carr, K., Wilkerson, C., Rensing, S.A, Gagneul, D., Dickenson, N., Oesterhelt, C., Lercher, M.J, Weber, A.P, (2013). Gene Transfer from Bacteria and Archaea Facilitated Evolution of an Extremophilic Eukaryote. Science, 339(6124), 1207-1210.
        • Dickenson, N., Choudhari, S., Adam, P.R, Kramer, R.M, Joshi, S.B, Middaugh, C.R, Picking, W.L, Picking, W.D, (2013). Oligomeric States of the Shigella Translocator Protein IpaB Provide Structural Insights into Formation of the Type III Secretion Translocon. Protein Science, 22(5), 614-27.
        • Dickenson, N., Arizmendi, O., Patil, M., Picking, W.D, Picking, W.L, (2013). The N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD. . Biochemistry
        • Lotlikar, S.R, Hnatusko, S.B, Dickenson, N., Choudhari, S.P, Picking, W.L, Patrauchan, M.A, (2013). Three functional carbonic anhydrases in P. aeruginosa PAO1. Role in survival in ambient air. Microbiology
        • Adam, P.R, Patil, M., Dickenson, N., Barta, M.L, Choudhari, S., Geisbrecht, B.V, Picking, W.L, Picking, W.D, (2012). Binding Affects the Tertiary and Quaternary Structures of the Shigella Translocator Protein IpaB and its Chaperone IpgC. Biochemistry, 51, 4062-4071.
        • Dickenson, N., Picking, W.D, (2012). FRET as a tool for dissecting molecular interactions within the bacterial type III secretion needle tip complex. International Journal of Molecular Sciences, 13(11), 15137-15161.
        • Barta, M.L, Dickenson, N., Patil, M., Picking, W.D, Picking, W.L, Geisbrecht, B.V, (2012). The crystal structures of coiled-coil domains from type three secretion system first translocator proteins reveal homology to pore-forming toxins. Journal of Molecular Biology, 417(5), 395-405.
        • Epler, C.R, Dickenson, N., Bullitt, E., Picking, W.L, (2012). Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus ofShigella flexneri. Journal of Molecular Biology, 420, 29-39.
        • Dickenson, N., Zhang, L., Epler, C.R, Adam, P.R, Picking, W.L, Picking, W.D, (2011). Conformational Changes in IpaD from Shigella flexneri Upon Binding Bile Salts Provide Insight into the Second Step of Type III Secretion. Biochemistry, 50, 172-180.
        • Barta, M.L, Guragain, M., Adam, P.R, Dickenson, N., Geisbrecht, B.V, Picking, W.L, Picking, W.D, (2011). Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure. Proteins, 80(3), 935-945.
        • Dickenson, N., Armendariz, K.P, Huckabay, H.A, Livanec, P.W, Dunn, R.C, (2010). Near-field scanning optical microscopy: a tool for nanometric exploration of biological membranes. Analytical and Bioanalytical Chemistry, 396(1), 31-43.
        • Epler, C.R, Dickenson, N., Olive, A.J, Picking, W.L, Picking, W.D, (2009). Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction. Infection and Immunity, 77(7), 2754-61.
        • Dickenson, N., Erickson, E.S, Mooren, O.L, Dunn, R.C, (2007). Characterization of Power Induced Heating and Damage in Fiber Optic Probes for Near-Field Scanning Optical Microscopy. Review of Scientific Instruments, 78, 53712-53716.
        • Dickenson, N., Moore, D., Suprenant, K.A, Dunn, R.C, (2007). Vault Ribonucleoprotein Particles and the Central Mass of the Nuclear Pore Complex. Photochemistry and Photobiology, 83, 1-6.
        • Mooren, O.L, Erickson, E.S, Dickenson, N., Dunn, R.C, (2006). Extending Near-Field Scanning Optical Microscopy for Biological Studies. Journal of the Association for Laboratory Automation, 11, 268- 272.

        * Has not been peer reviewed

        Publications - Literary Journal

          * Has not been peer reviewed

          Publications - MultiMedia

            * Has not been peer reviewed

            Publications - Technical Reports

              * Has not been peer reviewed

              Publications - Translations & Transcripts

                Publications - Other

                  * Has not been peer reviewed

                  Scheduled Teaching

                  CHEM 7800 - Seminar, Spring 2017

                  CHEM 6770 - Biochemical Methods, Fall 2016

                  CHEM 5700 - General Biochemistry I, Fall 2016

                  CHEM 4800 - Research Problems, Spring 2016

                  HONR 4900 - Senior Thesis/Project, Spring 2016

                  CHEM 7770 - Special Topics in Biochemistry (Topic), Spring 2016

                  CHEM 6700 - Advanced Biochemistry I, Fall 2015

                  CHEM 5070 - Biophysical Chemistry, Fall 2015

                  CHEM 5700 - General Biochemistry I, Fall 2015

                  CHEM 4800 - Research Problems, Fall 2015

                  CHEM 7800 - Seminar, Spring 2015

                  CHEM 6700 - Advanced Biochemistry I, Fall 2014

                  CHEM 7610 - Chemical Separations, Fall 2014

                  CHEM 5700 - General Biochemistry I, Fall 2014

                  CHEM 4800 - Research Problems, Fall 2014

                  CHEM 7800 - Seminar, Fall 2014

                  CHEM 5700,6700 - General Biochemistry I, Fall 2013


                  Graduate Students Mentored

                  Jamie Burgess, August 2016
                  Jamie Burgess, Chemistry & Biochemistry, August 2016
                  Heather Jones, Chemistry & Biochemistry, August 2015
                  Heather Jones, August 2015
                  Abram Bernard, Chemistry & Biochemistry, January 2014
                  Robert Burgess, Chemistry & Biochemistry, January 2014
                  Abram Bernard, Chemistry & Biochemistry, August 2013
                  Robert Burgess, Chemistry & Biochemistry, August 2013