Joan Hevel

Publications - Abstracts

• Bailey, S.W, Ayling, J.E, Hevel, J.M, (2005). Catalytic Efficiency of Dehydratase DCoHalpha, an Isozyme of Human 4a-Hydroxy tetrahydropterin (DCoH). Pteridines

Publications - Books & Book Chapters

* Has not been peer reviewed

Publications - Fact Sheets

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Publications - Curriculum

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Publications - Journal Articles

Academic Journal

• Caceres, T., Thakur, A., Price, O., Ippolito, N., Li, J., Qu, J., Acevedo, O., Hevel, J.M, (2018). Phe 71 in type III Trypanosomal protein arginine methyltransferase 7 (TbPRMT7) restricts the enzyme to monomethylation. Biochemistry, 57:8, 1349-1359. doi: https://doi.org/10.1021/acs.biochem.7b01265
• Gathiaka, S., Boykin, B., Caceres, T., Hevel, J.M, Acevedo, O., (2016). Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics. Bioorg Med Chem, 24, 4949-4960. doi: 10.1016/j.bmc.2016.08.009
• Morales, Y., Cáceres, T., May, K., Hevel, J.M, (2016). Biochemistry and regulation of the protein arginine methyltransferases (PRMTs).. Archives of biochemistry and biophysics, 590, 138-52.
• Morales, Y., Nitzel, D.V, Price, O.M, Gui, S., Li , J., Qu, J., Hevel, J.M, (2015). Redox Control of Protein Arginine Methyltransferase 1 (PRMT1) Activity.. The Journal of biological chemistry, 290:24, 14915-26.
• Gui, S., Gathiaka, S., Li, J., Qu, J., Acevedo, O., Hevel, J.M, (2014). A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine. Journal of Biological Chemistry, 289, 9320-7. doi: oi: 10.1074/jbc.M113.535278
• Wang, C., Zhu, Y., Caceres, T., Liu, L., Peng, J., Wang, J., Chen, X., Zhang, Z., Zuo, X., Gong, Q., Teng, M., Hevel, J.M, Wu, J., Shi, Y., (2014). Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7. Structure, doi: doi: 10.1016/j.str.2014.03.003
• Gui, S., Wooderchak, W.L, Zhang, T., Chen, D., Daly, M., Zhou, Z.S, Hevel, J.M, (2012). Substrate-induced control of product formation by protein arginine methyltransferase 1. Biochemistry, 52, 199-209. doi: 10.1021/bi301283t
• Gui, L., Wooderchak, W.L, Daly, M.P, Porter, P.J, Johnson, S.J, Hevel, J.M, (2011). Investigation of the Molecular Origins of Protein Arginine Methyltransferase I (PRMT1) Product Specificity Reveals a Role for Two Conserved Methionine Residues. Journal of Biological Chemistry, 286:33, 29118-26. doi: 10.1074/jbc.M111.224097
• Suh-Lailam, B.B, Hevel, J.M, (2010). Rapid, Quantitative Measurement of Protein Methyltransferase Activity. Analytical Biochemistry398, 218-224.
• Hevel, J.M, Pande, P., Oveson, S., Sudweeks, T., Hansen, C., Ayling, J.E, (2008). Determinants of Oligomerization of the Bifunctional Protein DCoH and the Effect on its Coactivator and Enzymatic Activities. Archives of Biochemistry and Biophysics477, 356-362.
• Suh-Lailam, B.B, Hevel, J.M, (2008). Efficient Cleavage of Problematic TEV-PRMT1 Constructs. Analytical Biochemistry387, 130-132.
• Hevel, J.M, Olson-Buelow, L., Ganesa, B., Stevens, J.R, Hardman, J.P, Aust, A.E, (2008). Novel Functional View of the Crocidolite-Treated A549 Human Lung Epithelial Transcriptome Reveals an Intricate Network of Pathways with Opposing Functions. BMC Genomics9, 376.
• Wooderchak, W.L, Zhang, T., Zhou, Z.S, Acuna, M., Tahara, S., Hevel, J.M, (2008). Substrate Profiling of PRMT1 Reveals Sequences that Go Beyond the ‘RGG’ Paradigm. Biochemistry47, 9456-9466.
• Wooderchak, W.L, Zhou, Z.S, Hevel, J.M, (2008). Assays for S-Adenosylmethionine (AdoMet/SAM)-Dependent Methyltransferses. Current Protocols in Toxicology
• Hevel, J.M, Olson-Buelow, L.C, Ganesan, B., Stevens, J.R, Hardman, J.P, Aust, A.E, (2008). Novel Functional View of the Crocidolite Asbestos-Treated Human Lung Transcriptome Illustrates Intricate Network of Pathways with Opposing Functions.. BMC Genomics, 9, 376.
• Dorgan, K.M, Wooderchak, W.L, Wynn, D.P, Karschner, E.L, Alfaro, J.F, Cuig, Y., Zhou, Z.S, Hevel, J.M, (2006). An Enzyme-Coupled Continuous Spectrophotometric Assay for S-Adenosylmethionine-Dependent Methyltransferases. Analytical Biochemistry, 350, doi: 249-255
• Hevel, J.M, Stewart, J.A, Gross, K.L, Ayling, J.E, (2006). Can the DCoHalpha Isozyme Compensate in Patients with 4a-Hydroxy-tetrahydrobiopterin Dehydratase/DCoH Deficiency? . Molecular Genetics and Metabolism, 88, 36.

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Publications - Literary Journal

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Publications - MultiMedia

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Publications - Technical Reports

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Publications - Translations & Transcripts

Publications - Other

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Scheduled Teaching

Graduate Students Mentored