Faculty | Chemistry
Joan Hevel

Biochemistry
Associate Professor
Associate Professor
Contact Information
Office Location: WIDT 235
DialPhone: (435) 797-1622
SendEmail: Joanie.Hevel@usu.edu
Educational Background
PhD, Medicinal Chemistry, University of Michigan, 1993 Dissertation
Purification and mechanistic studies of inducible nitric oxide synthase
Awards
COS Undergraduate Research Mentor of the Year 2011, 2011
Utah State UniversityPublications - Abstracts
- Bailey, S.W, Ayling, J.E, Hevel, J.M, (2005). Catalytic Efficiency of Dehydratase DCoHalpha, an Isozyme of Human 4a-Hydroxy tetrahydropterin (DCoH). Pteridines
Publications - Books & Book Chapters
* Has not been peer reviewed
Publications - Fact Sheets
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Publications - Curriculum
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Publications - Journal Articles
- Caceres, T., Thakur, A., Price, O., Ippolito, N., Li, J., Qu, J., Acevedo, O., Hevel, J.M, (2018). Phe 71 in type III Trypanosomal protein arginine methyltransferase 7 (TbPRMT7) restricts the enzyme to monomethylation. Biochemistry, 57:8, 1349-1359. doi: https://doi.org/10.1021/acs.biochem.7b01265
- Gathiaka, S., Boykin, B., Caceres, T., Hevel, J.M, Acevedo, O., (2016). Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics. Bioorg Med Chem, 24, 4949-4960. doi: 10.1016/j.bmc.2016.08.009
- Morales, Y., Cáceres, T., May, K., Hevel, J.M, (2016). Biochemistry and regulation of the protein arginine methyltransferases (PRMTs).. Archives of biochemistry and biophysics, 590, 138-52.
- Morales, Y., Nitzel, D.V, Price, O.M, Gui, S., Li , J., Qu, J., Hevel, J.M, (2015). Redox Control of Protein Arginine Methyltransferase 1 (PRMT1) Activity.. The Journal of biological chemistry, 290:24, 14915-26.
- Gui, S., Gathiaka, S., Li, J., Qu, J., Acevedo, O., Hevel, J.M, (2014). A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine. Journal of Biological Chemistry, 289, 9320-7. doi: oi: 10.1074/jbc.M113.535278
- Wang, C., Zhu, Y., Caceres, T., Liu, L., Peng, J., Wang, J., Chen, X., Zhang, Z., Zuo, X., Gong, Q., Teng, M., Hevel, J.M, Wu, J., Shi, Y., (2014). Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7. Structure, doi: doi: 10.1016/j.str.2014.03.003
- Gui, S., Wooderchak, W.L, Zhang, T., Chen, D., Daly, M., Zhou, Z.S, Hevel, J.M, (2012). Substrate-induced control of product formation by protein arginine methyltransferase 1. Biochemistry, 52, 199-209. doi: 10.1021/bi301283t
- Gui, L., Wooderchak, W.L, Daly, M.P, Porter, P.J, Johnson, S.J, Hevel, J.M, (2011). Investigation of the Molecular Origins of Protein Arginine Methyltransferase I (PRMT1) Product Specificity Reveals a Role for Two Conserved Methionine Residues. Journal of Biological Chemistry, 286:33, 29118-26. doi: 10.1074/jbc.M111.224097
- Suh-Lailam, B.B, Hevel, J.M, (2010). Rapid, Quantitative Measurement of Protein Methyltransferase Activity. Analytical Biochemistry398, 218-224.
- Hevel, J.M, Pande, P., Oveson, S., Sudweeks, T., Hansen, C., Ayling, J.E, (2008). Determinants of Oligomerization of the Bifunctional Protein DCoH and the Effect on its Coactivator and Enzymatic Activities. Archives of Biochemistry and Biophysics477, 356-362.
- Suh-Lailam, B.B, Hevel, J.M, (2008). Efficient Cleavage of Problematic TEV-PRMT1 Constructs. Analytical Biochemistry387, 130-132.
- Hevel, J.M, Olson-Buelow, L., Ganesa, B., Stevens, J.R, Hardman, J.P, Aust, A.E, (2008). Novel Functional View of the Crocidolite-Treated A549 Human Lung Epithelial Transcriptome Reveals an Intricate Network of Pathways with Opposing Functions. BMC Genomics9, 376.
- Wooderchak, W.L, Zhang, T., Zhou, Z.S, Acuna, M., Tahara, S., Hevel, J.M, (2008). Substrate Profiling of PRMT1 Reveals Sequences that Go Beyond the ‘RGG’ Paradigm. Biochemistry47, 9456-9466.
- Wooderchak, W.L, Zhou, Z.S, Hevel, J.M, (2008). Assays for S-Adenosylmethionine (AdoMet/SAM)-Dependent Methyltransferses. Current Protocols in Toxicology
- Hevel, J.M, Olson-Buelow, L.C, Ganesan, B., Stevens, J.R, Hardman, J.P, Aust, A.E, (2008). Novel Functional View of the Crocidolite Asbestos-Treated Human Lung Transcriptome Illustrates Intricate Network of Pathways with Opposing Functions.. BMC Genomics, 9, 376.
- Dorgan, K.M, Wooderchak, W.L, Wynn, D.P, Karschner, E.L, Alfaro, J.F, Cuig, Y., Zhou, Z.S, Hevel, J.M, (2006). An Enzyme-Coupled Continuous Spectrophotometric Assay for S-Adenosylmethionine-Dependent Methyltransferases. Analytical Biochemistry, 350, doi: 249-255
- Hevel, J.M, Stewart, J.A, Gross, K.L, Ayling, J.E, (2006). Can the DCoHalpha Isozyme Compensate in Patients with 4a-Hydroxy-tetrahydrobiopterin Dehydratase/DCoH Deficiency? . Molecular Genetics and Metabolism, 88, 36.
Academic Journal
* Has not been peer reviewed
Publications - Literary Journal
* Has not been peer reviewed
Publications - MultiMedia
* Has not been peer reviewed
Publications - Technical Reports
* Has not been peer reviewed
Publications - Translations & Transcripts
Publications - Other
* Has not been peer reviewed
Scheduled Teaching
BIOL, CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Fall 2020
CHEM 1990 - Introduction to the Chemistry and Biochemistry Professions, Fall 2020
CHEM 5710 - General Biochemistry II, Spring 2020
CHEM 1990 - Introduction to the Chemistry and Biochemistry Professions, Fall 2019
CHEM 7770 - Special Topics in Biochemistry (Topic), Fall 2019
CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2019
CHEM 5710 - General Biochemistry II, Spring 2019
CHEM 7800 - Seminar, Fall 2018
CHEM 4890 - Undergraduate Biochemistry Seminar, Fall 2018
CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2018
CHEM 5710 - General Biochemistry II, Spring 2018
CHEM 4800 - Research Problems, Spring 2018
CHEM 1990 - Introduction to the Chemistry and Biochemistry Professions, Fall 2017
CHEM 4800 - Research Problems, Fall 2017
CHEM 7770 - Special Topics in Biochemistry (Topic), Fall 2017
CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2017
CHEM 5710 - General Biochemistry II, Spring 2017
CHEM 4890 - Undergraduate Biochemistry Seminar, Fall 2016
CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2016
CHEM 5710 - General Biochemistry II, Spring 2016
CHEM 4800 - Research Problems, Spring 2016
CHEM 4890 - Undergraduate Biochemistry Seminar, Spring 2016
CHEM 5070 - Biophysical Chemistry, Fall 2015
CHEM 4800 - Research Problems, Fall 2015
CHEM 7770 - Special Topics in Biochemistry (Topic), Fall 2015
CHEM 6710 - Advanced Biochemistry II, Spring 2015
CHEM 5710 - General Biochemistry II, Spring 2015
CHEM 4800 - Research Problems, Spring 2015
CHEM 7770 - Special Topics in Biochemistry (Topic), Spring 2015
CHEM 1990 - Introduction to the Chemistry and Biochemistry Professions, Fall 2014
CHEM 4890 - Undergraduate Biochemistry Seminar, Fall 2014
BIOL,CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2014
CHEM 5710,6710 - General Biochemistry II, Spring 2014
CHEM 4800 - Research Problems, Spring 2014
CHEM 4800 - Research Problems, Summer 2013
CHEM 5710 - General Biochemistry II, Spring 2013
CHEM 4800 - Research Problems, Spring 2013
CHEM 1210 - Principles of Chemistry I, Fall 2012
CHEM 1210 - Principles of Chemistry I, Fall 2012
CHEM 1210 - Principles of Chemistry I, Fall 2012
CHEM 6970 - Thesis Research, Summer 2012
Chem 6710 - Advanced Biochemistry II, Spring 2012
CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2012
Chem 6740 - Cellular Comunication by Small Molecules and Proteins, Spring 2012
Chem 7970 - Dissertation Research, Spring 2012
Chem 5710 - General Biochemistry II, Spring 2012
CHEM 5710,6710 - General Biochemistry II, Spring 2012
CHEM 4800 - Research Problems, Spring 2012
Chem 6970 - Thesis Research, Spring 2012
Chem 4800 - Undergraduate Research Problems, Spring 2012
CHEM 4800 - Research Problems, Fall 2011
CHEM 6710 - ADV BIOCHEMISTRY II, Spring 2011
CHEM 4890 - BIOCHEMISTRY SEMINAR (CI), Spring 2011
CHEM 7970 - DISSERTATION RSRCH, Spring 2011
CHEM 5710 - GENERAL BIOCHEM II, Spring 2011
CHEM 4800 - RESEARCH PROBLEMS (CI), Spring 2011
CHEM 7800 - SEMINAR, Spring 2011
CHEM 7800 - ST: BIOCHEMISTRY SEMINAR, Spring 2011
BIOL 6750 - ST: CHEMICAL BIOLOGY METH II, Spring 2011
BIOL 7750 - ST: CHEMICAL BIOLOGY METH II, Spring 2011
CHEM 7770 - TOPICS:CHEMICAL BIOL METH II, Spring 2011
CHEM 7970 - PhD Dissertation Research, Fall 2010
CHEM 4800 - Research Problems, Fall 2010
CHEM 7800 - Seminar, Fall 2010
CHEM 7800 - Seminar, Fall 2010
CHEM 7770 - Special Topics in Biochemistry (Topic), Fall 2010
CHEM 4890 - Undergraduate Biochemistry Seminar, Fall 2010
Graduate Students Mentored
Drake Comer, Chemistry & Biochemistry
Owen Price, August 2016
Ariana Ortolano, Chemistry & Biochemistry, January 2017 - November 2019
Kyle May, August 2013 - May 2018
Tamar Caceres, Chemistry & Biochemistry, August 2011 - May 2018
Yalemi Morales, Chemistry & Biochemistry 2016
Celeste Excell, Chemistry & Biochemistry, April 2012 - April 2014
Shanying Gui, Chemistry & Biochemistry 2013
Damon Nitzel, Chemistry & Biochemistry, August 2011 - May 2013
Brenda Suh-Lailam, 2010