Label-free discrimination and quantitative analysis of oxidative stress induced cytotoxicity and potential protection of antioxidants using Raman micro-spectroscopy and machine learning
Cheng-Wei Tom Chang. Diesel exhaust particles (DEPs) are major constituents of air pollution and associated with numerous oxidative stress-induced human diseases. In vitro toxicity studies are useful for developing a better understanding of species-spec
Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels
Cheng-Wei T. Chang, Yagya P. Subedi, Paul Roberts, Heath Montgomery, Noah Thakeray. Gap junction channels formed by the association of connexin hemichannels play a crucial role in intercellular communication. Connexin 43 (Cx43) is expressed in a variety
Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study
Alvan C. Hengge. Phosphate and sulfate esters have important roles in regulating cellular processes. However, while there has been substantial experimental and computational investigation of the mechanisms and the transition states involved in phosphate
Selective Inhibition of Different Isoforms of Connexin Hemichannels by New Aminoglycosides
Cheng-Wei T. Chang, Yagya P. Subedi, Madher N. AlFindee. Connexins hemichannels (HCs) from adjacent cells form gap-junctional channels that mediate cell-to-cell communication. Abnormal opening of “free” undocked HCs can produce cell damage and particip
An Alternative and Facile Synthetic Approach for the Precursors of 3- and 6-Aminosugar Donors and Study of One-pot Glycosyltrasferation
Cheng-Wei Tom Chang, Uddav Pandey, Yagya Prasad Subedi, Madher N. Alfindee, Taylor Shepherd. 3- and 6-aminosugars are common motifs in bioactive compounds playing pivotal roles in the bioactivity of the core molecules to which they are attached. Howev
Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6"-Modified amphiphilic kanamycins
Cheng-Wei Tom Chang, Yagya Prasad Subedi, Uddav Pandey, Madher N. Alfindee Amphiphilic kanamycins bearing hydrophobic modifications at the 6″ position have attracted interest due to remarkable antibacterial-to-antifungal switches in bioactivity. In this
Antifungal Activities of 4",6"-Disubstituted Amphiphilic Kanamycins
Cheng-Wei T. Chang, Yagya P. Subedi, Madher N. Alfindee Amphiphilic kanamycins derived from the classic antibiotic kanamycin have attracted interest due to their novel bioactivities beyond inhibition of bacteria. In this study, the recently described 4
Natural Bioactive Compounds
Cheng-Wei Tom Chang Nature has long provided us with molecules for therapeutic applications limited only by the imagination and creativity of mankind. Ancient civilizations such as those that once existed in China, Greece, India and Egypt left numerous ex...
Cheng-Wei T. Chang Living things on Earth depend on heme – the iron‐cyclic tetrapyrrole complex that harnesses iron's oxidizing powers. Heme is toxic, but Nature has evolved ways to control it. One way is breaking it with heme oxygenase which lowers its l...
Facile fabrication of periodic arrays of vertical Si nanoholes on (001)Si substrate with broadband light absorption properties
C.W. Chang This study presents a facile and straightforward approach to fabricating periodic arrays of Au nanodisks and vertically aligned, depth- and morphology-controllable Si nanoholes on (001)Si substrates by combining self-assembled nanosphere
Inhibition of Connexion Hemichannels by New Aminoglycosids without Antibiotic Activity
Cheng-Wei T. Chang, Yagya P. Subedi, Madher N. Alfindee
Development of Fungal Selective Amphiphilic Kanamycin: Cost-Effective Synthesis and Use of Fluorescent Analogs for Mode of Action Investigation
Cheng-Wei Tom Chang, Yagya Prasad Subedi Amphiphilic aminoglycosides have attracted interest due to their novel antifungal activities. A crucial but often neglected factor for drug development in academia is cost of production. Herein is reported a one-st...
Cationic Anthrquinone Analogs as Selective Antimicrobials
Cheng-Wei Tom Chang, Yagya Prasad Subedi Development of new antibiotics is always needed in the fight against growing threat from multiple drug–resistant bacteria, such as resistant Gram-negative (G−) Escherichia coli and Klebsiella pneumoniae. While
Tuning the biological activity of cationic anthraquinone analogues specifically toward staphylococcus aureus
Yagya Prasad Subedi, madher N. Alfindee, Jaya P. Shestha, and Cheng-Wei Tom Chang Abstract: Development of new antibacterial agents against drug resistant bacteria is an imminent task, especially against methicillin-resistant Staphylococcus aureus (MRSA)....
Synthesis and biological activity investigation of azole and quinone hybridized phosphonates
Yagya Prasad Subedi, Madher N. Alfindee, Jaya P. Shrestha, Greg Becker, Michelle Grilley, Jon Y. Takemoto, Cheng-Wei Tom Chang ABSTRACT: Phosphonates, azoles and quinones are pharmacophores found in bioactive compounds. A series of phosphonates conjugated...
Inhibition of connexin hemichannels by new amphiphilic aminoglycosides without antibiotic activity
Madher N. Alfindee, Yagya P. Subedi, Mariana C. Fiori, Srinivasan Krishnan, Abbey Kjellgren, Guillermo A. Altenberg, and Cheng-Wei T. Chang ABSTRACT: Connexins hemichannels (HCs) from adjacent cells form gap junctional channels that mediate cell-to-cell c...
Antifungal amphiphilic kanamycins: new life for an old drug
Yagya Prasad Subedi, Madher N. Alfinee, Jon Y. Takemoto and Cheng-Wei Tom Chang Classical aminoglycoside antibiotics are obsolete or hampered by the emergence of drug resistant bacteria. Recent discoveries of antifungal amphiphilic kanamycins offer new
Excitonic and confinement effects of 2D layered (C10H21NH3) 2PbBr4 single crystals
Huatao Yin, Lei Jin, Yuqin Qian, Xia Li, Yuhao Wu, Michael S. Bowen, Deirdre Kaan, Chao He, Derek I Wozniak, Bolei Xu, Asa J Lewis, Weiwei Shen, Ke Chen, Graham E Dobereiner, Yan Zhao, Bradford B Wayland, Yi Rao Recognition of unusual optoelectronic prop...
A sulfonate-functionalized viologen enabling neutral cation exchange, aqueous organic redox flow batteries toward renewable energy storage
Camden DeBruler, Bo Hu, Jared Moss, Jian Luo, and T. Leo Liu: Redox flow batteries using synthetically tunable and resource abundant organic molecules have gained increasing attention for large-scale energy storage. Herein we report a sulfonate-functional...