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Joan Hevel

Profile Picture

Biochemistry

Associate Professor

Associate Professor

Educational Background

PhD, Medicinal Chemistry, University of Michigan, 1993
Purification and mechanistic studies of inducible nitric oxide synthase
BS, Chemistry, (Biochemistry), Lebanon Valley College, 1988

Awards

Undergraduate Research Mentor of the Year 2011, 2011

Utah State University

Publications - Abstracts

  • Bailey, S.W, Ayling, J.E, Hevel, J.M, (2005). Catalytic Efficiency of Dehydratase DCoHalpha, an Isozyme of Human 4a-Hydroxy tetrahydropterin (DCoH). Pteridines

Publications - Books & Book Chapters

    * Has not been peer reviewed

    Publications - Fact Sheets

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      Publications - Curriculum

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        Publications - Journal Articles

          Academic Journal

        • Gathiaka, S., Boykin, B., Caceres, T., Hevel, J.M, Acevedo, O., (2016). Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics. Bioorg Med Chem, 24, 4949-4960. doi: 10.1016/j.bmc.2016.08.009
        • Morales, Y., Cáceres, T., May, K., Hevel, J.M, (2016). Biochemistry and regulation of the protein arginine methyltransferases (PRMTs).. Archives of biochemistry and biophysics, 590, 138-52.
        • Morales, Y., Nitzel, D.V, Price, O.M, Gui, S., Li , J., Qu, J., Hevel, J.M, (2015). Redox Control of Protein Arginine Methyltransferase 1 (PRMT1) Activity.. The Journal of biological chemistry, 290:24, 14915-26.
        • Gui, S., Gathiaka, S., Li, J., Qu, J., Acevedo, O., Hevel, J.M, (2014). A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine. Journal of Biological Chemistry, 289, 9320-7. doi: oi: 10.1074/jbc.M113.535278
        • Wang, C., Zhu, Y., Caceres, T., Liu, L., Peng, J., Wang, J., Chen, X., Zhang, Z., Zuo, X., Gong, Q., Teng, M., Hevel, J.M, Wu, J., Shi, Y., (2014). Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7. Structure, doi: doi: 10.1016/j.str.2014.03.003
        • Gui, S., Wooderchak, W.L, Zhang, T., Chen, D., Daly, M., Zhou, Z.S, Hevel, J.M, (2012). Substrate-induced control of product formation by protein arginine methyltransferase 1. Biochemistry, 52, 199-209. doi: 10.1021/bi301283t
        • Gui, L., Wooderchak, W.L, Daly, M.P, Porter, P.J, Johnson, S.J, Hevel, J.M, (2011). Investigation of the Molecular Origins of Protein Arginine Methyltransferase I (PRMT1) Product Specificity Reveals a Role for Two Conserved Methionine Residues. Journal of Biological Chemistry, 286:33, 29118-26. doi: 10.1074/jbc.M111.224097
        • Suh-Lailam, B.B, Hevel, J.M, (2010). Rapid, Quantitative Measurement of Protein Methyltransferase Activity. Analytical Biochemistry398, 218-224.
        • Hevel, J.M, Pande, P., Oveson, S., Sudweeks, T., Hansen, C., Ayling, J.E, (2008). Determinants of Oligomerization of the Bifunctional Protein DCoH and the Effect on its Coactivator and Enzymatic Activities. Archives of Biochemistry and Biophysics477, 356-362.
        • Suh-Lailam, B.B, Hevel, J.M, (2008). Efficient Cleavage of Problematic TEV-PRMT1 Constructs. Analytical Biochemistry387, 130-132.
        • Hevel, J.M, Olson-Buelow, L., Ganesa, B., Stevens, J.R, Hardman, J.P, Aust, A.E, (2008). Novel Functional View of the Crocidolite-Treated A549 Human Lung Epithelial Transcriptome Reveals an Intricate Network of Pathways with Opposing Functions. BMC Genomics9, 376.
        • Wooderchak, W.L, Zhang, T., Zhou, Z.S, Acuna, M., Tahara, S., Hevel, J.M, (2008). Substrate Profiling of PRMT1 Reveals Sequences that Go Beyond the ‘RGG’ Paradigm. Biochemistry47, 9456-9466.
        • Wooderchak, W.L, Zhou, Z.S, Hevel, J.M, (2008). Assays for S-Adenosylmethionine (AdoMet/SAM)-Dependent Methyltransferses. Current Protocols in Toxicology
        • Hevel, J.M, Olson-Buelow, L.C, Ganesan, B., Stevens, J.R, Hardman, J.P, Aust, A.E, (2008). Novel Functional View of the Crocidolite Asbestos-Treated Human Lung Transcriptome Illustrates Intricate Network of Pathways with Opposing Functions.. BMC Genomics, 9, 376.
        • Dorgan, K.M, Wooderchak, W.L, Wynn, D.P, Karschner, E.L, Alfaro, J.F, Cuig, Y., Zhou, Z.S, Hevel, J.M, (2006). An Enzyme-Coupled Continuous Spectrophotometric Assay for S-Adenosylmethionine-Dependent Methyltransferases. Analytical Biochemistry, 350, doi: 249-255
        • Hevel, J.M, Stewart, J.A, Gross, K.L, Ayling, J.E, (2006). Can the DCoHalpha Isozyme Compensate in Patients with 4a-Hydroxy-tetrahydrobiopterin Dehydratase/DCoH Deficiency? . Molecular Genetics and Metabolism, 88, 36.

        * Has not been peer reviewed

        Publications - Literary Journal

          * Has not been peer reviewed

          Publications - MultiMedia

            * Has not been peer reviewed

            Publications - Technical Reports

              * Has not been peer reviewed

              Publications - Translations & Transcripts

                Publications - Other

                  * Has not been peer reviewed

                  Scheduled Teaching

                  CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2017

                  CHEM 5710 - General Biochemistry II, Spring 2017

                  CHEM 4890 - Undergraduate Biochemistry Seminar, Fall 2016

                  CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2016

                  CHEM 5710 - General Biochemistry II, Spring 2016

                  CHEM 4800 - Research Problems, Spring 2016

                  CHEM 4890 - Undergraduate Biochemistry Seminar, Spring 2016

                  CHEM 5070 - Biophysical Chemistry, Fall 2015

                  CHEM 4800 - Research Problems, Fall 2015

                  CHEM 7770 - Special Topics in Biochemistry (Topic), Fall 2015

                  CHEM 6710 - Advanced Biochemistry II, Spring 2015

                  CHEM 5710 - General Biochemistry II, Spring 2015

                  CHEM 4800 - Research Problems, Spring 2015

                  CHEM 7770 - Special Topics in Biochemistry (Topic), Spring 2015

                  CHEM 1990 - Introduction to the Chemistry and Biochemistry Professions, Fall 2014

                  CHEM 4890 - Undergraduate Biochemistry Seminar, Fall 2014

                  BIOL,CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2014

                  CHEM 5710,6710 - General Biochemistry II, Spring 2014

                  CHEM 4800 - Research Problems, Spring 2014

                  CHEM 4800 - Research Problems, Summer 2013

                  CHEM 5710 - General Biochemistry II, Spring 2013

                  CHEM 4800 - Research Problems, Spring 2013

                  CHEM 1210 - Principles of Chemistry I, Fall 2012

                  CHEM 1210 - Principles of Chemistry I, Fall 2012

                  CHEM 1210 - Principles of Chemistry I, Fall 2012

                  CHEM 6970 - Thesis Research, Summer 2012

                  Chem 6710 - Advanced Biochemistry II, Spring 2012

                  CHEM 6740 - Cellular Communication by Small Molecules and Proteins, Spring 2012

                  Chem 6740 - Cellular Comunication by Small Molecules and Proteins, Spring 2012

                  Chem 7970 - Dissertation Research, Spring 2012

                  Chem 5710 - General Biochemistry II, Spring 2012

                  CHEM 5710,6710 - General Biochemistry II, Spring 2012

                  CHEM 4800 - Research Problems, Spring 2012

                  Chem 6970 - Thesis Research, Spring 2012

                  Chem 4800 - Undergraduate Research Problems, Spring 2012

                  CHEM 4800 - Research Problems, Fall 2011

                  CHEM 6710 - ADV BIOCHEMISTRY II, Spring 2011

                  CHEM 4890 - BIOCHEMISTRY SEMINAR (CI), Spring 2011

                  CHEM 7970 - DISSERTATION RSRCH, Spring 2011

                  CHEM 5710 - GENERAL BIOCHEM II, Spring 2011

                  CHEM 4800 - RESEARCH PROBLEMS (CI), Spring 2011

                  CHEM 7800 - SEMINAR, Spring 2011

                  CHEM 7800 - ST: BIOCHEMISTRY SEMINAR, Spring 2011

                  BIOL 6750 - ST: CHEMICAL BIOLOGY METH II, Spring 2011

                  BIOL 7750 - ST: CHEMICAL BIOLOGY METH II, Spring 2011

                  CHEM 7770 - TOPICS:CHEMICAL BIOL METH II, Spring 2011

                  CHEM 7970 - PhD Dissertation Research, Fall 2010

                  CHEM 4800 - Research Problems, Fall 2010

                  CHEM 7800 - Seminar, Fall 2010

                  CHEM 7800 - Seminar, Fall 2010

                  CHEM 7770 - Special Topics in Biochemistry (Topic), Fall 2010

                  CHEM 4890 - Undergraduate Biochemistry Seminar, Fall 2010


                  Graduate Students Mentored

                  Ariana Ortolano, January 2017
                  Owen Price, August 2016
                  Kyle May, August 2013
                  Tamar Caceres, Chemistry & Biochemistry, August 2011
                  Yalemi Morales, Chemistry & Biochemistry 2016
                  Celeste Excell, Chemistry & Biochemistry, April 2012 - April 2014
                  Shanying Gui, Chemistry & Biochemistry 2013
                  Damon Nitzel, Chemistry & Biochemistry, August 2011 - May 2013
                  Brenda Suh-Lailam, 2010