Skip to main content

Alvan Hengge

Profile Picture

Organic Chemistry

Department Head and Professor

Professor

Educational Background

PhD, Organic Chemistry, University of Cincinnati, 1987
BS, Community Services and Chemical Engineering, University of Cincinnati, 1974

Awards

D. Wynne Thorne Career Research Award, 2015

Utah State University

Undergraduate Research Mentor of the Year, 2008

USU College of Science

Researcher of the Year, 2006

USU College of Science

Teacher of the Year, 2005

USU College of Science

NIH Postdoctoral Fellow, 1987

National Institutes of health

Lowenstein-Schubert-Twitchell Graduate Fellowship, 1986

University of Cincinnati

College of Engineering Scholastic Achievement Award, 1973

University of Cincinnati

Publications - Abstracts

  • Anderson, S.N, Nziko, Vincent de Paul Nzuwah, , Chang, C.T, Hengge, A.C, (2014). Enhancing safety in academic research laboratories: Creating a studentbased safety committee. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Whittier, S., Hengge, A.C, Loria, J.P, (2013). Coupling of Loop Closure and Chemistry in Protein Tyrosine Phosphatases. BIOPHYSICAL JOURNAL *
  • Chu, Y., Hengge, A.C, Williams, N.H, (2012). A Simple Arg to Lys Mutant of Protein Phosphatase 1 Exhibits CatalyticEfficiencies toward Monoanionic Substrates Superior to Wild Type. FASEB JOURNAL *
  • Kuznetsov, V.I, Johnson, S.J, Hengge, A.C, (2012). High resolution structure of the phosphatase VHZ explains unexpectedsubstrate specificity, and suggests the presence of metavanadate at theactive site. FASEB JOURNAL *
  • Haney, M.P, Hengge, A.C, (2012). The phosphoramidase competency of prototypical phosphatase motifs. FASEB JOURNAL *
  • Smith, G.K, Ke, Z., Hengge, A.C, Xu, D., Xie, D., Guo, H., (2010). Active-site dynamics of the SpvC virulence factor from Salmonellatyphimurium and density functional model for the catalytic mechanism ofthe phosphthreonine lyase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Chu, Y., Williams, N.H, Hengge, A.C, (2010). Mechanistic study of phosphoryl transfer reactions catalyzed by proteinphosphatase-1. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Huefner, S.A, Brandao, T.A, Johnson, S.J, Hengge, A.C, (2008). CHED 176-Protein-tyrosine phosphatases: Comparing the effects ofmutation on protein conformation and catalysis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Brandao, T.A, Huefner, S.A, Johnson, S.J, Hengge, A.C, (2008). BIOL 97-Protein conformational changes in catalysis by protein-tyrosinephosphatases. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Tanifum, E.A, Hengge, A.C, Lund, E.A, Williams, N.H, Feng, G., McWhirter, C., (2007). ORGN 724-Comparative mechanistic studies on the catalyticallypromiscuous serine/threonine protein phosphatase-1 (PP-1) and thedinuclear cobalt(III) complex [Co2(tacn)2(OH)3](ClO4)3. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Iyer, S., Hengge, A.C, (2007). Effect of thio-substitution on the mechanisms of transesterification ofribonucleoside phosphodiester models. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Sorensen-Stowell, K., Hengge, A.C, (2005). Use of O-18 isotope shifts on P-31 NMR to probe potential medium effectson phosphate ester bond strengths.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Humphry, T., Forconi, M., Williams, N., Hengge, A.C, (2003). Alteration of the mechanisms of phosphate ester hydrolysis bycomplexation to a dinuclear metal cneter.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Swierczek, K., Hengge, A.C, (2003). Comparison of phosphonothioic acids with phosphonic acids as inhibitorsof phosphatase.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Purcell, J., Hengge, A.C, (2003). Mechanistic studies of phosphoryl and thiophosphoryl group transfer.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Younker, J., Hengge, A.C, (2003). Mechanistic study of aryl aryl sulfate diesters.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Iyer, S., Younker, J., Czyryca, P., Hengge, A.C, (2003). Synthesis and evaluation of aryloxymethyl and aryloxyethyl phosphonatesas inhibitors of phosphatases.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hengge, A.C, Catrina, I., (2002). Are phosphorothioates valid mechanistic probes for enzymatic phosphoryltransfer?. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hengge, A.C, Humphry, T., Forconi, M., Williams, N., (2001). Mechanism of reaction of phosphate esters coordinated to a model ofdinuclear metallophosphatases.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  • Hengge, A.C, Grzyska, P., Czyryca, P., Golightly, J., Small, K., Larsen, P., Hoff, R., (2001). Medium effects on phosphoryl transfer reactions and their possibleapplicability to enzymatic phosphoryl transfer.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hengge, A.C, Czyryca, P., (2001). Novel motif for the design of transition state analogs for phosphatases.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hengge, A.C, (2001). Transition states for phosphoryl transfer reactions of phosphatases andtheir application to inhibitor design.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hengge, A.C, Czyryca, P., (2001). A novel motif for the design of transition state analogues for phosphatases.. BIOCHEMISTRY *
  • Hengge, A.C, Humphry, T., Forconi, M., Williams, N., (2001). Mechanism of reaction of phosphate esters coordinated to a model ofdinuclear metallophosphatases.. BIOCHEMISTRY *
  • Rawlings, J., Hengge, A.C, Cleland, W., (1999). Cn(III)and Zn(II) catalyzed hydrolysis of phosphodiesters.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hoff, R., Hengge, A.C, (1998). Entropy effects in the catalytic efficiency of phosphatases. FASEB JOURNAL *
  • Catrina, I., Hengge, A.C, (1998). Solution and enzymatic reactions of phosphorothioate monoesters:Thermodynamics and mechanisms. FASEB JOURNAL *
  • Hoff, R., Hengge, A.C, (1997). Thermodynamics of solvation effects on phosphoryl and sulfuryl.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hengge, A.C, Zhang, Z., Denu, J., Dixon, J., (1996). Isotope effect studies of the dual-specific phosphatases VHR and STP1. FASEB JOURNAL *
  • RAWLINGS, J., Hengge, A.C, CLELAND, W., (1995). HEAVY-ATOM ISOTOPE EFFECTS ON CO(III)-CATALYZED HYDROLYSIS OFP-NITROPHENYLPHOSPHATE. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
  • Hengge, A.C, ZHANG, Z., (1995). KINETIC ISOTOPE EFFECTS ON REACTIONS OF TYROSINE PHOSPHATASES. FASEB JOURNAL *
  • RAWLINGS, J., Hengge, A.C, CLELAND, W., (1994). ISOTOPE EFFECTS ON THE HYDROLYSIS OF COBALT(III)-BOUND PHOSPHATE-ESTERS. FASEB JOURNAL *

Publications - Books & Book Chapters

    Book Chapters

  • Chu, Y., Hengge, A.C, (2010). Phosphatases: Encyclopedia of Catalysis, Second Edition.
  • Brandao, T.A, Hengge, A.C, (2010). Phosphoryl and Sulfuryl Transfer: Comprehensive Natural Products II: Chemistry and Biology. Elsevier
  • Hengge, A.C, (2005). Mechanistic studies on enzyme-catalyzed phosphoryl transfer: ADVANCES IN PHYSICAL ORGANIC CHEMISTRY, VOL 40.

* Has not been peer reviewed

Publications - Fact Sheets

    * Has not been peer reviewed

    Publications - Curriculum

      * Has not been peer reviewed

      Publications - Journal Articles

        Academic Journal

      • Chu, Y., Williams, N.H, Hengge, A.C, (2017). Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1. Biochemistry, 56:30, 3923-3933. doi: 10.1021/acs.biochem.7b00441
      • Pereira, M.S, Murta, B., Oliveira, T.C, Manfredi, A.M, Nome, F., Hengge, A.C, Brandao, T.A, (2016). Mechanistic Aspects of Phosphate Diester Cleavage Assisted by Imidazole.A Template Reaction for Obtaining Aryl Phosphoimidazoles. Journal of Organic Chemistry, 81:19, 8663-8672.
      • Coitinho, J.B, Pereira, M.S, Costa, D.M, Guimaraes, S.L, Araujo, S.S, Hengge, A.C, Brandao, T.A, Nagem, R.A, (2016). Structural and Kinetic Properties of the Aldehyde Dehydrogenase NahF, aBroad Substrate Specificity Enzyme for Aldehyde Oxidation. Biochemistry, 55:38, 5453-5463. doi: 10.1021/acs.biochem.6b00614
      • Hengge, A.C, (2015). Kinetic Isotope Effects In The Characterization Of Catalysis by Protein Tyrosine Phosphatases. Biochemica et Biophysica Acta - Proteins and Proteomics , 1854, 1768-1775. doi: 10.1016/j.bbapap.2015.03.010
      • Moise, G., Gallup, N.M, Alexandrova, .N, Hengge, A.C, Johnson, S.J, (2015). Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54:42, 6490-6500. doi: 10.1021/acs.biochem.5b00496
      • Hengge, A.C, (2013). Chemistry and mechanism of phosphatases, diesterases and triesterases. Biochimica et Biophysica Acta, 1834:1, 415-416. doi: 10.1016/j.bbapap.2012.09.013
      • Whittier, S.K, Hengge, A.C, Loria, J.P, (2013). Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases. Science, 341, 899-903. doi: 10.1126/science.1241735
      • Kuznetsov, V.I, Hengge, A.C, (2013). New Functional Aspects of the Atypical Protein Tyrosine Phosphatase VHZ. Biochemistry, 52:45, 8012-8025. doi: 10.1021/bi400776z
      • Hengge, A.C, (2013). Chemistry and mechanism of phosphatases, diesterases and triesterasesPreface. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834:1, 415-416.
      • Hengge, A.C, Kuznetsov, V.I, Alexandrova, A.N, (2012). Metavanadate at the Active Site of the Phosphatase VHZ. Journal of the American Chemical Society, 134:35, 14298-14301. doi: 10.1021/ja305579h
      • Kuznetsov, V.I, Hengge, A.C, Johnson, S.J, (2012). New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening.. Biochemistry, 51:49, 9869-9879. doi: 10.1021/bi300908y
      • Brandao, T.A, Johnson, S.J, Hengge, A.C, (2012). The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Archives of Biochemistry and Biophysics, 525:1, 53-59. doi: doi.org/10.1016/j.abb.2012.06.002
      • Smith, G.K, Ke, Z., H.G, Hengge, A.C, (2011). Insights into the Phosphoryl Transfer Mechanism of Cyclin-Dependent Protein Kinases from ab Initio QM/MM Free-Energy Studies. Journal of Physical Chemistry B, 115:46, 13713-13722.
      • Mitic, N., Hadler, K.S, Gahan, L.R, Hengge, A.C, Schenk, G., (2010). The Divalent Metal Ion in the Active Site of Uteroferrin Modulates Substrate Binding and Catalysis. Journal of the American Chemical Society, 132:20, 7049-7054. doi: 10.1021/ja910583y
      • Brandao, T.A, Hengge, A.C, Johnson, S.J, (2010). Insights into the reaction of protein tyrosine phosphatase 1B. Crystal structures for transition-state analogs of both catalytic steps. Journal of Biological Chemistry, 285:21, 15874-15883. doi: 10.1074/jbc.M109.066951
      • Smith, G.K, Ke, Z., Hengge, A.C, Xu, D., Xie, D., Guo, H., (2009). Active-Site Dynamics of SpvC Virulence Factor from Salmonella typhimurium and Density Functional Theory Study of Phosphothreonine Lyase Catalysis. Journal of Physical Chemistry B, 113:46, 15327-15333. doi: 10.1021/jp9052677
      • Brandao, T.A, Robinson, H., Johnson, S.J, Hengge, A.C, (2009). Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. Journal of the American Chemical Society, 131:2, 778-786.
      • Feng, G., Tanifum, E.A, Adams, H., Hengge, A.C, Williams, N.H, (2009). Mechanism and Transition State Structure of Aryl Methylphosphonate Esters Doubly Coordinated to a Dinuclear Cobalt(III) Center. Journal of the American Chemistry Society, 131:35, 12771-12779. doi: 10.1021/ja904134n
      • Humphry, T., Iyer, S., Iranzo, O., Morrow, J.R, Richard, J.P, Paneth, P., Hengge, A.C, (2008). Altered Transition State for the Reaction of an RNA Model Catalyzed by aDinuclear Zinc(II) Catalyst. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130:52, 17858-17866.
      • Humphry, T., Iyer, S., Iranzo, O., Morrow, J.R, Richard, J.P, Paneth, P., Hengge, A.C, (2008). An Altered Transition State for the Reaction of an RNA Model Catalyzed by a Dinuclear Zinc(II) Catalyst. Journal of the American Chemistry Society, 130:52, 17858-17866.
      • McWhirter, C., Lund, E.A, Tanifum, E.A, Feng, G., Sheikh, Q.L, Hengge, A.C, Williams, N.H, (2008). Mechanistic Study of Protein Phosphatase-1 (PP1), A Catalytically Promiscuous Enzyme. Journal of the American Chemistry Society, 130:41, 13673-13682.
      • Hadler, K.S, Tanifum, E.A, Yip, S.H, Mitic, N., Guddat, L.W, Jackson, C.J, Gahan, L.R, Nguyen, K., Carr, P.D, Ollis, D.L, Hengge, A.C, Larrabee, J.A, Schenk, G., (2008). Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes. Journal of the American Chemistry Society, 130:41, 14129-14138.
      • Iyer, S., Hengge, A.C, (2008). The Effects of Sulfur Substitution for the Nucleophile and Bridging Oxygen Atoms in Reactions of Hydroxyalkyl Phosphate Esters. Journal of Organic Chemistry, 73:13, 4819-4829.
      • Brandao, T.A, Robinson, H., Johnson, S.J, Hengge, A.C, (2008). Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. Journal of the American Chemical Society, 131:2, 778-786. doi: 10.1021/ja807418b
      • Cox, R.S, Schenk, G., Mitic, N., Gahan, L., Hengge, A.C, (2007). Diesterase Activity and Substrate Binding in Purple Acid Phosphatases. J. Am. Chem. Soc., 129:31, 9550-9551.
      • Zalatan, J.G, Catrina, I., Mitchell, R., Grzyska, P.K, O'Brien, P.J, Herschlag, D., Hengge, A.C, (2007). Kinetic Isotope Effects for Alkaline Phosphatase Reactions: Implications for the Role of Active-Site Metal Ions in Catalysis. J. Am. Chem. Soc., 129:31, 9789-9796.
      • Wong, F.M, Wang, J., Hengge, A.C, Wu, W., (2007). Mechanism of Rhodium-Catalyzed Carbene Formation from Diazo Compounds. Org. Lett., 9:9, 1663-1665.
      • Catrina, I., O'Brien, P.J, Purcell, J., Nikolic-Hughes, I., Zalatan, J.G, Hengge, A.C, Herschlag, D., (2007). Probing the Origin of the Compromised Catalysis of E. coli Alkaline Phosphatase in its Promiscuous Sulfatase Reaction. J. Am. Chem. Soc. , 129:17, 5760-5765.
      • Hoff, R.H, Hengge, A.C, (2007). The Use of Isotopes in the Study of Reactions of Acyl, Phosphoryl, and Sulfuryl Esters. Journal of Labelled Compounds and Radiopharmaceuticals, 50, 1026-1038.
      • Lund, E.A, Hengge, A.C, Williams, N.H, McWhirter, C., Feng, G., (2007). Mechanistic study of PP-1, a catalytically promiscuous enzyme. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 233, 613.
      • Rawlings, J., Cleland, W.W, Hengge, A.C, (2006). Metal-catalyzed phosphodiester cleavage: Secondary O-18 isotope effectsas an indicator of mechanism. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128:51, 17120-17125.
      • Hoff, R.H, Czyryca, P.G, Sun, M., Leyh, T.S, Hengge, A.C, (2006). Transition state of the sulfuryl transfer reaction of estrogensulfotransferase. JOURNAL OF BIOLOGICAL CHEMISTRY, 281:41, 30645-30649.
      • Sorensen-Stowell, K., Hengge, A.C, (2006). Thermodynamic origin of the increased rate of hydrolysis of phosphateand phosphorothioate esters in DMSO/water mixtures. JOURNAL OF ORGANIC CHEMISTRY, 71:19, 7180-7184.
      • Cleland, W.W, Hengge, A.C, (2006). Enzymatic mechanisms of phosphate and sulfate transfer. CHEMICAL REVIEWS, 106:8, 3252-3278.
      • Liu, Y., Gregersen, B.A, Hengge, A.C, York, D.M, (2006). Transesterification thio effects of phosphate diesters: Free energybarriers and kinetic and equilibrium isotope effects fromdensity-functional theory. BIOCHEMISTRY, 45:33, 10043-10053.
      • Sorensen-Stowell, K., Hengge, A.C, (2005). Probing potential medium effects on phosphate ester bonds using O-18isotope shifts on P-31 NMR. JOURNAL OF ORGANIC CHEMISTRY, 70:21, 8303-8308.
      • Purcell, J., Hengge, A.C, (2005). Thermodynamics of phosphate versus phosphorothioate ester hydrolysis. JOURNAL OF ORGANIC CHEMISTRY, 70:21, 8437-8442.
      • Onyido, I., Swierczek, K., Purcell, J., Hengge, A.C, (2005). A concerted mechanism for the transfer of the thiophosphinoyl group fromaryl dimethylphosphinothioate esters to oxyanionic nucleophiles inaqueous solution. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127:21, 7703-7711.
      • Sorensen-Stowell, K., Hengge, A.C, (2005). Examination of P-OR bridging bond orders in phosphate monoesters usingO-18 isotope shifts in P-31 NMR. JOURNAL OF ORGANIC CHEMISTRY, 70:12, 4805-4809.
      • Hengge, A.C, Onyido, I., (2005). Physical organic perspectives on phospho group transfer from phosphatesand phosphinates. CURRENT ORGANIC CHEMISTRY, 9:1, 61-74.
      • Younker, J., Hengge, A.C, (2004). A mechanistic study of the alkaline hydrolysis of diaryl sulfatediesters. JOURNAL OF ORGANIC CHEMISTRY, 69:26, 9043-9048.
      • Iyer, S., Younker, J., Czyryca, P., Hengge, A.C, (2004). A nohydrolyzale analogue of phosphotyrosine, and related aryloxymethano-and aryloxyethano-phosponic acids as motifs for inhibition ofphosphatases. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14:23, 5931-5935.
      • Humphry, T., Forconi, M., Williams, N., Hengge, A.C, (2004). Altered mechanisms of reactions of phosphate esters bridging a dinuclearmetal center. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126:38, 11864-11869.
      • Grzyska, P., Kim, Y., Jackson, M., Hengge, A.C, Denu, J., (2004). Probing the transition-state structure of dual-specificity proteinphosphatases using a physiological substrate mimic. BIOCHEMISTRY, 43:27, 8807-8814.
      • Gibby, S., Younker, J., Hengge, A.C, (2004). Investigation of the sulfuryl transfer step from substrate to enzyme byarylsulfatases. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 17:6-7, 541-547.
      • McCain, D., Grzyska, P., Wu, L., Hengge, A.C, Zhang, Z., (2004). Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25Awith m-nitrobenzyl phosphate. BIOCHEMISTRY, 43:25, 8256-8264.
      • Hengge, A.C, Stein, R., (2004). Role of protein conformational mobility in enzyme catalysis: Acylationof alpha-chymotrypsin by specific peptide substrates. BIOCHEMISTRY, 43:3, 742-747.
      • Grzyska, P., Czyryca, P., Purcell, J., Hengge, A.C, (2003). Transition state differences in hydrolysis reactions of alkyl versusaryl phosphate monoester monoanions. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125:43, 13106-13111.
      • Swierczek, K., Pandey, A., Peters, J., Hengge, A.C, (2003). A comparison of phosphonothioic acids with phosphonic acids asphosphatase inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, 46:17, 3703-3708.
      • Iyer, S., Younker, J., Czyryca, P., Hengge, A.C, (2003). Synthesis and evaluation of aryloxymethyl and aryloxyethyl phosphonatesas inhibitors of phosphatases.. BIOCHEMISTRY, 42:28, 8600-8601.
      • Catrina, I., Hengge, A.C, (2003). Comparisons of phosphorothioate with phosphate transfer reactions for amonoester, diester, and triester: Isotope effect studies. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125:25, 7546-7552.
      • Swierczek, K., Peters, J., Hengge, A.C, (2003). A convenient synthesis of phosphonothioic acids. TETRAHEDRON, 59:5, 595-599.
      • Rawlings, J., Cleland, W., Hengge, A.C, (2003). Metal ion catalyzed hydrolysis of ethyl p-nitrophenyl phosphate. JOURNAL OF INORGANIC BIOCHEMISTRY, 93:1-2, 61-65.
      • Humphry, T., Forconi, M., Williams, N., Hengge, A.C, (2002). An altered mechanism of hydrolysis for a metal-complexed phosphatediester. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124:50, 14860-14861.
      • Catrina, I., Czyryca, P., Hengge, A.C, (2002). Isotope effects on enzymatic and nonenzymatic reactions ofphosphorothioates. NUKLEONIKA, 47:1, S17-S23.
      • McCain, D., Catrina, I., Hengge, A.C, Zhang, Z., (2002). The catalytic mechanism of Cdc25A phosphatase. JOURNAL OF BIOLOGICAL CHEMISTRY, 277:13, 11190-11200.
      • Grzyska, P., Czyryca, P., Golightly, J., Small, K., Larsen, P., Hoff, R., Hengge, A.C, (2002). Generality of solvation effects on the hydrolysis rates of phosphatemonoesters and their possible relevance to enzymatic catalysis. JOURNAL OF ORGANIC CHEMISTRY, 67:4, 1214-1220.
      • Hengge, A.C, (2002). Isotope effects in the study of phosphoryl and sulfuryl transferreactions. ACCOUNTS OF CHEMICAL RESEARCH, 35:2, 105-112.
      • Hoff, R., Larsen, P., Hengge, A.C, (2001). Isotope effects and medium effects on sulfuryl transfer reactions. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123:38, 9338-9344.
      • Hengge, A.C, (2001). Isotope effects in the study of enzymatic phosphoryl transfer reactions. FEBS LETTERS, 501:2-3, 99-102.
      • Hengge, A.C, Grzyska, P., Czyryca, P., Golightly, J., Small, K., Larsen, P., Hoff, R., (2001). Medium effects on phosphoryl transfer reactions and their possibleapplicability to enzymatic phosphoryl transfer.. BIOCHEMISTRY, 40:29, 8622-8623.
      • Czyryca, P., Hengge, A.C, (2001). The mechanism of the phosphoryl transfer catalyzed by Yersiniaprotein-tyrosine phosphatase: a computational and isotope effect study. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1547:2, 245-253.
      • Rigas, J., Hoff, R., Rice, A., Hengge, A.C, Denu, J., (2001). Transition state analysis and requirement of Asp-262 general acid/basecatalyst for full activation of dual-specificity phosphatase MKP3 byextracellular regulated kinase. BIOCHEMISTRY, 40:14, 4398-4406.
      • Rishavy, M., Hengge, A.C, Cleland, W., (2000). Lanthanide catalyzed cyclization of uridine 3 ‘-p-nitrophenyl phosphate. BIOORGANIC CHEMISTRY, 28:5, 283-292.
      • Holtz, K., Catrina, I., Hengge, A.C, Kantrowitz, E., (2000). Mutation of Arg-166 of alkaline phosphatase alters the thio effect butnot the transition state for phosphoryl transfer. Implications for theinterpretation of thio effects in reactions of phosphatases. BIOCHEMISTRY, 39:31, 9451-9458.
      • Hengge, A.C, Bruzik, K., Tobin, A., Cleland, W., Tsai, M., (2000). Kinetic isotope effects and stereochemical studies on a ribonucleasemodel: Hydrolysis reactions of uridine 3 ‘-nitrophenyl phosphate. BIOORGANIC CHEMISTRY, 28:3, 119-133.
      • Hoff, R., Hengge, A.C, Wu, L., Keng, Y., Zhang, Z., (2000). Effects on general acid catalysis from mutations of the invarianttryptophan and arginine residues in the protein tyrosine phosphatasefrom Yersinia. BIOCHEMISTRY, 39:1, 46-54.
      • Hoff, R., Wu, L., Zhou, B., Zhang, Z., Hengge, A.C, (1999). Does positive charge at the active sites of phosphatases cause a changein mechanism? The effect of the conserved arginine on the transitionstate for phosphoryl transfer in the protein-tyrosine phosphatase fromYersinia. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 121:41, 9514-9521.
      • Hoff, R., Mertz, P., Rusnak, F., Hengge, A.C, (1999). The transition state of the phosphoryl-transfer reaction catalyzed bythe lambda Ser/Thr protein phosphatase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 121:27, 6382-6390.
      • Martin, B., Jurado, L., Hengge, A.C, (1999). Comparison of the reaction progress of calcineurin with Mn2+ and Mg2+. BIOCHEMISTRY, 38:11, 3386-3392.
      • Catrina, I., Hengge, A.C, (1999). Comparisons of phosphorothioate and phosphate monoester transferreactions: Activation parameters, solvent effects, and the effect ofmetal ions. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 121:10, 2156-2163.
      • Hoff, R., Hengge, A.C, (1998). Entropy and enthalpy contributions to solvent effects on phosphatemonoester solvolysis. The importance of entropy effects in thedissociative transition state. JOURNAL OF ORGANIC CHEMISTRY, 63:19, 6680-6688.
      • Hess, R., Hengge, A.C, Cleland, W., (1998). Isotope effects on enzyme-catalyzed acyl transfer from p-nitrophenylacetate: Concerted mechanisms and increased hyperconjugation in thetransition state. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 120:12, 2703-2709.
      • Hoff, R., Hengge, A.C, (1998). A facile high-yield synthesis and purification of tetrabutylammoniumtetrabutylborate. JOURNAL OF ORGANIC CHEMISTRY, 63:1, 195.
      • Catrina, I., Hengge, A., (1997). The thermodynamics, pH behavior, and effect of metal ions in reactionsof phosphorothioates.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 214:1, 242-INOR. *
      • Hengge, A., Martin, B., (1997). Isotope effect studies on the calcineurin phosphoryl-transfer reaction:Transition state structure and effect of calmodulin and Mn2+. BIOCHEMISTRY, 36:33, 10185-10191.
      • Hess, R., Hengge, A., Cleland, W., (1997). Kinetic isotope effects for acyl transfer from p-nitrophenyl acetate tohydroxylamine show a pH-dependent change in mechanism. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 119:30, 6980-6983.
      • Hengge, A., Zhao, Y., Wu, L., Zhang, Z., (1997). Examination of the transition state of the low-molecular mass smalltyrosine phosphatase .1. Comparisons with other protein phosphatases. BIOCHEMISTRY, 36:25, 7928-7936.
      • Sowa, G., Hengge, A., Cleland, W., (1997). O-18 isotope effects support a concerted mechanism for ribonuclease A. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 119:9, 2319-2320.
      • Rawlings, J., Hengge, A., Cleland, W., (1997). Heavy-atom isotope effects on reactions of Co(III)-bound p-nitrophenylphosphate: Nucleophilic displacements of p-nitrophenol and dissociationof p-nitrophenyl phosphate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 119:3, 542-549.
      • Hengge, A., Denu, J., Dixon, J., (1996). Transition-state structures for the native dual-specific phosphatase VHRand D92N and S131A mutants, contributions to the driving force forcatalysis. BIOCHEMISTRY, 35:22, 7084-7092.
      • Deal, K., Hengge, A.C, Burstyn, J., (1996). Characterization of transition states indichloro(1,4,7-triazacyclononane)copper(II)-catalyzed activatedphosphate diester hydrolysis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 118:7, 1713-1718.
      • Cleland, W., Hengge, A., (1995). Mechanisms of phosphoryl and acyl transfer. FASEB JOURNAL, 9:15, 1585-1594.
      • Hengge, A.C, SOWA, G., WU, L., ZHANG, Z., (1995). NATURE OF THE TRANSITION-STATE OF THE PROTEIN-TYROSINEPHOSPHATASE-CATALYZED REACTION. BIOCHEMISTRY, 34:43, 13982-13987.
      • Hengge, A.C, TOBIN, A., CLELAND, W., (1995). STUDIES OF TRANSITION-STATE STRUCTURES IN PHOSPHORYL TRANSFER-REACTIONSOF PHOSPHODIESTERS OF P-NITROPHENOL. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 117:22, 5919-5926.
      • Hengge, A.C, HESS, R., (1994). CONCERTED OR STEPWISE MECHANISMS FOR ACYL TRANSFER-REACTIONS OFP-NITROPHENYL ACETATE - TRANSITION-STATE STRUCTURES FROM ISOTOPE EFFECTS. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116:25, 11256-11263.
      • Hengge, A.C, EDENS, W., ELSING, H., (1994). TRANSITION-STATE STRUCTURES FOR PHOSPHORYL-TRANSFER REACTIONS OFP-NITROPHENYL PHOSPHATE. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116:12, 5045-5049.
      • Hengge, A.C, (1992). CAN ACYL TRANSFER OCCUR VIA A CONCERTED MECHANISM - DIRECT EVIDENCE FROMHEAVY-ATOM ISOTOPE EFFECTS. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 114:16, 6575-6576.
      • Hengge, A.C, (1992). O-18 EXCHANGE IN NITROPHENOLS - SIGNIFICANCE FOR LABELING AND ISOTOPEEFFECT EXPERIMENTS. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 114:7, 2747-2748.
      • WILSON, R., Hengge, A.C, ATAEI, A., HO, D., (1991). OXIDATIVE-ALPHA COUPLING OF CARBONYL-COMPOUNDS VIA THE CONDENSATION OFACYLATED TRIAZOLINEDIONE YLIDES WITH ENOLATES - A FACILE SYNTHESIS OFPOLYACYLATED OLEFINS. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113:19, 7240-7249.
      • Hengge, A.C, CLELAND, W., (1991). PHOSPHORYL-TRANSFER REACTIONS OF PHOSPHODIESTERS - CHARACTERIZATION OFTRANSITION-STATES BY HEAVY-ATOM ISOTOPE EFFECTS. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113:15, 5835-5841.
      • Hengge, A.C, CLELAND, W., (1991). MECHANISM OF PHOSPHODIESTER CLEAVAGE WITH BETA-CYCLODEXTRIN. JOURNAL OF ORGANIC CHEMISTRY, 56:5, 1972-1974.
      • Hengge, A.C, CLELAND, W., (1990). DIRECT MEASUREMENT OF TRANSITION-STATE BOND-CLEAVAGE IN HYDROLYSIS OFPHOSPHATE-ESTERS OF P-NITROPHENOL. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 112:20, 7421-7422.
      • WILSON, R., Hengge, A.C, ATAEI, A., CHANTARASIRI, N., (1990). ADDITION OF 4-PHENYLTRIAZOLINEDIONE TO CARBONYL-COMPOUNDS - THEFORMATION OF ALPHA-URAZOLYLCARBONYL COMPOUNDS. JOURNAL OF ORGANIC CHEMISTRY, 55:1, 193-197.
      • WILSON, R., Hengge, A.C, (1990). SYNTHESIS AND CHEMISTRY OF ACYLTRIAZOLINEDIONE YLIDES AND RELATEDINTERMEDIATES - NEW METHODS FOR THE PREPARATION OF DICARBONYL ANDTRICARBONYL COMPOUNDS. JOURNAL OF ORGANIC CHEMISTRY, 55:1, 197-202.
      • WILSON, R., Hengge, A.C, (1987). NUCLEOPHILIC ADDITIONS TO TRIAZOLINEDIONE YLIDES, EXTREMELY REACTIVECARBONYL EQUIVALENTS - A NEW CLASS OF CONDENSATION-REACTIONS. JOURNAL OF ORGANIC CHEMISTRY, 52:13, 2699-2707.
      • WILSON, R., Hengge, A.C, (1985). THE CHEMISTRY OF AN AZOMETHINE IMINE DERIVED FROM 2,3-DIMETHYLINDOLE ANDN-PHENYL TRIAZOLINEDIONE - A NEW AND FACILE CONDENSATION METHOD. TETRAHEDRON LETTERS, 26:31, 3673-3676.

      * Has not been peer reviewed

      Publications - Literary Journal

        * Has not been peer reviewed

        Publications - MultiMedia

          * Has not been peer reviewed

          Publications - Technical Reports

            * Has not been peer reviewed

            Publications - Translations & Transcripts

              Publications - Other

                Other

              • Hengge, A.C, (2008). NMR data do not implicate a phosphorane in the T4 DNA ligase reaction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OFAMERICA *

              * Has not been peer reviewed

              Scheduled Teaching

              CHEM 6990 - Continuing Graduate Advisement, Spring 2017

              CHEM 7990 - Continuing Graduate Advisement, Spring 2017

              CHEM 4800 - Research Problems, Spring 2017

              CHEM 7800 - Seminar, Spring 2017

              CHEM 7990 - Continuing Graduate Advisement, Fall 2016

              CHEM 2310 - Organic Chemistry I, Fall 2016

              CHEM 7800 - Seminar, Fall 2016

              CHEM 6990 - Continuing Graduate Advisement, Summer 2016

              CHEM 7990 - Continuing Graduate Advisement, Summer 2016

              CHEM 6300 - Advanced Modern Organic Chemistry, Spring 2016

              CHEM 6990 - Continuing Graduate Advisement, Spring 2016

              CHEM 7990 - Continuing Graduate Advisement, Spring 2016

              CHEM 6990 - Continuing Graduate Advisement, Fall 2015

              CHEM 7990 - Continuing Graduate Advisement, Fall 2015

              CHEM 6250 - Curricular Practical Training, Fall 2015

              CHEM 7990 - Continuing Graduate Advisement, Summer 2015

              CHEM 7990 - Continuing Graduate Advisement, Spring 2015

              CHEM 6990 - Continuing Graduate Advisement, Fall 2014

              CHEM 7990 - Continuing Graduate Advisement, Fall 2014

              CHEM 2310 - Organic Chemistry I, Fall 2014

              CHEM 7990 - Continuing Graduate Advisement, Summer 2014

              CHEM 7990 - Continuing Graduate Advisement, Spring 2014

              CHEM 6300 - Advanced Modern Organic Chemistry, Fall 2013

              CHEM 6990 - Continuing Graduate Advisement, Fall 2013

              CHEM 7990 - Continuing Graduate Advisement, Fall 2013

              CHEM 4250 - Cooperative Experience, Fall 2013

              CHEM 6990 - Continuing Graduate Advisement, Summer 2013

              CHEM 7990 - Continuing Graduate Advisement, Summer 2013

              CHEM 6990 - Continuing Graduate Advisement, Spring 2013

              CHEM 7990 - Continuing Graduate Advisement, Spring 2013

              CHEM 6990 - Continuing Graduate Advisement, Fall 2012

              CHEM 7990 - Continuing Graduate Advisement, Fall 2012

              CHEM 4250 - Cooperative Experience, Fall 2012

              CHEM 6250 - Curricular Practical Training, Fall 2012

              CHEM 2310 - Organic Chemistry I, Fall 2012

              CHEM 7990 - Continuing Graduate Advisement, Summer 2012

              CHEM 6990 - Continuing Graduate Advisement, Spring 2012

              CHEM 7990 - Continuing Graduate Advisement, Spring 2012

              CHEM 4800 - Research Problems, Spring 2012

              CHEM 6300 - Advanced Modern Organic Chemistry, Fall 2011

              CHEM 7990 - Continuing Graduate Advisement, Summer 2011

              CHEM 7990 - CONT GRAD ADVISEMENT, Spring 2011

              CHEM 7970 - DISSERTATION RSRCH, Spring 2011

              CHEM 2320 - ORGANIC CHEMISTRY II, Spring 2011

              CHEM 4800 - RESEARCH PROBLEMS (CI), Spring 2011

              CHEM 7800 - SEMINAR, Spring 2011

              CHEM 7800 - ST: ORGAN/INORGAN SEMINAR, Spring 2011

              CHEM 6970 - THESIS RESEARCH, Spring 2011

              CHEM 7990 - Continuing Graduate Advisement, Fall 2010

              CHEM 7970 - PhD Dissertation Research, Fall 2010

              CHEM 7800 - Seminar, Fall 2010

              CHEM 7800 - Seminar, Fall 2010

              CHEM 6970 - Thesis Research, Fall 2010


              Graduate Students Mentored

              Gwen Moise, Chemistry & Biochemistry, August 2011
              Teisha Richan, Chemistry & Biochemistry, August 2013 - June 2016
              Vyascheslov Kuznetsov, Chemistry & Biochemistry 2013
              Alok Shenoy, Chemistry & Biochemistry 2012
              Mark Haney, Chemistry & Biochemistry 2012
              Yuan Chu, Chemistry & Biochemistry - April 2012
              Subashree Iyer, Chemistry & Biochemistry 2007
              Robynn Cox, Chemistry & Biochemistry 2007
              Kerensa Sorensen-Stowell, Chemistry & Biochemistry 2006
              Tim Humphrey, Chemistry & Biochemistry 2006
              Jamie Purcell, Chemistry & Biochemistry, June 2001 - August 2005
              Piotr Grzyska, Chemistry & Biochemistry, January 1999 2003
              Irina Catrina, Chemistry & Biochemistry 2001
              Richard Hoff, Chemistry & Biochemistry 1999